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Δ9‐Tetrahydrocannabinol promotes functional remyelination in the mouse brain

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Research on demyelinating disorders aims to find novel molecules that are able to induce oligodendrocyte precursor cell differentiation to promote central nervous system remyelination and functional recovery. Δ9‐Tetrahydrocannabinol (THC), the… Click to show full abstract

Research on demyelinating disorders aims to find novel molecules that are able to induce oligodendrocyte precursor cell differentiation to promote central nervous system remyelination and functional recovery. Δ9‐Tetrahydrocannabinol (THC), the most prominent active constituent of the hemp plant Cannabis sativa, confers neuroprotection in animal models of demyelination. However, the possible effect of THC on myelin repair has never been studied.

Keywords: remyelination; tetrahydrocannabinol; tetrahydrocannabinol promotes; promotes functional; functional remyelination; remyelination mouse

Journal Title: British Journal of Pharmacology
Year Published: 2021

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