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Protective role of cortistatin in pulmonary inflammation and fibrosis

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Acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and pulmonary fibrosis remain major causes of morbidity, mortality and a healthcare burden in critically ill patient. There is an urgent… Click to show full abstract

Acute lung injury (ALI), acute respiratory distress syndrome (ARDS) and pulmonary fibrosis remain major causes of morbidity, mortality and a healthcare burden in critically ill patient. There is an urgent need to identify factors causing susceptibility and for the design of new therapeutic agents. Here, we evaluate the effectiveness of the immunomodulatory neuropeptide cortistatin to regulate pulmonary inflammation and fibrosis in vivo.

Keywords: inflammation fibrosis; pulmonary inflammation; fibrosis; cortistatin; protective role

Journal Title: British Journal of Pharmacology
Year Published: 2021

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