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Mucin‐fused myeloid‐derived growth factor (MYDGF164) exhibits a prolonged serum half‐life and alleviates fibrosis in chronic kidney disease

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Although no effective therapy is available to stop or reverse CKD progression targeting its key feature, the loss of peritubular capillaries (PTCs) leading to interstitial fibrosis, myeloid‐derived growth factor (MYDGF)… Click to show full abstract

Although no effective therapy is available to stop or reverse CKD progression targeting its key feature, the loss of peritubular capillaries (PTCs) leading to interstitial fibrosis, myeloid‐derived growth factor (MYDGF) with tissue‐repairing activities enlightens its therapeutic potential for CKD. However, the extremely short circulatory lifetime (15 min) restricts its application.

Keywords: derived growth; myeloid derived; growth factor; mucin fused

Journal Title: British Journal of Pharmacology
Year Published: 2022

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