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Anti‐inflammatory effects of cannabidiol against lipopolysaccharides in cardiac sodium channels

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Sepsis, caused by a dysregulated response to infections, can lead to cardiac arrhythmias. However, the mechanisms underlying sepsis‐induced inflammation, and how inflammation provokes cardiac arrhythmias, are not well understood. We… Click to show full abstract

Sepsis, caused by a dysregulated response to infections, can lead to cardiac arrhythmias. However, the mechanisms underlying sepsis‐induced inflammation, and how inflammation provokes cardiac arrhythmias, are not well understood. We hypothesized that cannabidiol (CBD) may ameliorate lipopolysaccharide (LPS)‐induced cardiotoxicity, via Toll‐like receptors (TLR4) and cardiac sodium channels (NaV1.5).

Keywords: sodium channels; effects cannabidiol; anti inflammatory; inflammatory effects; cardiac sodium

Journal Title: British Journal of Pharmacology
Year Published: 2022

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