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Calcaratarin D, a labdane diterpenoid, attenuates mouse asthma via modulating alveolar macrophage function

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Alveolar macrophages (AMs) contribute to airway inflammation and remodelling in allergic asthma. Calcaratarin D (CalD), a labdane diterpenoid from rhizomes of the medicinal plant Alpinia calcarata, has recently been shown… Click to show full abstract

Alveolar macrophages (AMs) contribute to airway inflammation and remodelling in allergic asthma. Calcaratarin D (CalD), a labdane diterpenoid from rhizomes of the medicinal plant Alpinia calcarata, has recently been shown to possess anti‐inflammatory properties. The present study evaluated protective effects of CalD in a house dust mite (HDM)‐induced asthma mouse model.

Keywords: asthma via; mouse asthma; calcaratarin labdane; diterpenoid attenuates; labdane diterpenoid; attenuates mouse

Journal Title: British Journal of Pharmacology
Year Published: 2022

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