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Standard pharmacological analysis of agonist activity utilises measurements of receptor‐mediated responses at a set time‐point, or at the peak response level, to characterise ligands. However, the occurrence of non‐equilibrium conditions… Click to show full abstract
Standard pharmacological analysis of agonist activity utilises measurements of receptor‐mediated responses at a set time‐point, or at the peak response level, to characterise ligands. However, the occurrence of non‐equilibrium conditions may dramatically impact the properties of the response being measured. Here we have analysed the initial kinetic phases of cAMP responses to β2‐adrenoceptor agonists in HEK293 cells expressing the endogenous β2‐adrenoceptor at extremely low levels.
Journal Title: British Journal of Pharmacology
Year Published: 2022
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