Chronic inflammation plays a pivotal role in the development of Type 2 diabetes mellitus (T2DM). Previous studies have shown that haem oxygenase‐1 (HO‐1) plays a proinflammatory role during metabolic stress,… Click to show full abstract
Chronic inflammation plays a pivotal role in the development of Type 2 diabetes mellitus (T2DM). Previous studies have shown that haem oxygenase‐1 (HO‐1) plays a proinflammatory role during metabolic stress, suggesting that HO‐1 inhibition could be an effective strategy to treat T2DM. However, the application of HO‐1 inhibitors is restricted due to solubility‐limited bioavailability. In this study, we encapsulated the HO‐1 inhibitor, zinc protoporphyrin IX (ZnPP), within nanoparticles and investigated their role in regulating glucose homeostasis and chronic inflammation during obesity.
Journal Title: British Journal of Pharmacology
Year Published: 2024
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!