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Synthesis and activity of the salicylic acid ester of bakuchiol in psoriasis‐surrogate keratinocytes and skin substitutes

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Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity,… Click to show full abstract

Topical retinoids are effective in retarding skin ageing and restoring homeostasis in skin conditions such as psoriasis. However their adverse effects (AEs), which include irritation (retinoid dermatitis), photosensitivity and teratogenicity, limit their use and patient compliance. Development of retinoid analogues with minimal AEs would allow a broader and more compliant use.

Keywords: salicylic acid; acid ester; activity salicylic; ester bakuchiol; bakuchiol psoriasis; synthesis activity

Journal Title: Clinical and Experimental Dermatology
Year Published: 2017

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