LAUSR

Pemphigoid nodularis (PN) is a rare variant of bullous pemphigoid (BP), manifesting with clinical features of prurigo nodularis with an autoantibody profile of BP. Psoralen ultraviolet A (PUVA) can induce blister formation acrally and in areas with friction or trauma. While this is generally distinct from BP, these blisters represent the initial manifestation of BP in some patients, and are thus considered PUVA-induced BP. A 73-year-old East Asian man presented with a vesiculobullous eruption following four treatments of oral PUVA for recalcitrant pruritus with prurigo nodules. Other than prurigo nodules and excoriations, the patient originally lacked other cutaneous manifestations. The initial cause of the patient’s pruritus was unclear. He had previously been prophylactically treated with permethrin, topical corticosteroids, pramoxine and gabapentin with little improvement. The patient’s other medications included amlodipine, aspirin, atorvastatin, apixaban, escitalopram and metoprolol. He had not had a biopsy taken prior to the start of his PUVA treatment and basic laboratory investigations at the time were unremarkable. On physical examination, the patient was found to have prurigo nodules and excoriations (Fig. 1), along with numerous coalescing vesicles and tense bullae on his hands, trunk and thighs. Histological examination of a biopsy taken from an intact vesicle demonstrated vesicular spongiotic dermatitis with numerous eosinophils (Fig. 2). Indirect immunofluorescence demonstrated linear staining for IgG along the basement membrane zone (BMZ) at a titre of 1 : 40 960 on monkey oesophagus, and an epidermal staining pattern on salt-split skin at a dilution of 1 : 5120. ELISA results for IgG to BP180 and BP230 were 114 and 59 ELISA units/mL, respectively, with a reference range of 9 ELISA units/mL for both tests. Therefore, a diagnosis of PN was made. The patient was successfully treated with a combination of a slow prednisone taper, intravenous IgG 2 g/kg/month, minocycline 100 mg twice daily, niacinamide 500 mg three times daily, and mycophenolate mofetil 1 g twice daily, as is standard in our immunobullous clinic to achieve durable remissions. The patient was successfully weaned off prednisone, and his other medications were continued. PN is a rare variant of BP. Although patients demonstrate an immunological phenotype of BP, some do not develop blisters. Similar nonbullous phenomena occur in patients with significant levels of BP antibodies in other pruritic disorders of the elderly, and PN is