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Localized scleroderma (LSc) or morphea is an autoimmune inflammatory disorder of the skin and underlying tissues, such as subcutaneous fat, fascia, muscles and bones, resulting in extensive fibrosis and irreversible… Click to show full abstract
Localized scleroderma (LSc) or morphea is an autoimmune inflammatory disorder of the skin and underlying tissues, such as subcutaneous fat, fascia, muscles and bones, resulting in extensive fibrosis and irreversible deformity. Since linear scleroderma, a subset of LSc, represents skin lesions distributed along with Blaschko's lines, LSc is thought to be caused by tissue damage due to immune-medicated elimination of cells originally derived from a single somatically mutated ectodermal progenitor cell.
Journal Title: Clinical and Experimental Dermatology
Year Published: 2020
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