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Induction and exacerbation of subacute cutaneous lupus erythematosus following mRNA‐based or adenoviral vector‐based SARS‐CoV‐2 vaccination

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Evidence is accumulating that COVID‐19 vaccines might induce or exacerbate autoimmune rheumatic diseases. The currently available COVID‐19 vaccines include mRNA and recombinant adenoviral vector vaccines, both encoding SARS‐CoV‐2 spike protein… Click to show full abstract

Evidence is accumulating that COVID‐19 vaccines might induce or exacerbate autoimmune rheumatic diseases. The currently available COVID‐19 vaccines include mRNA and recombinant adenoviral vector vaccines, both encoding SARS‐CoV‐2 spike protein production as the primary target for neutralizing antibodies. We report a case of subacute cutaneous lupus erythematosus (SCLE) following mRNA vaccination with the Pfizer mRNA vaccine BNT162b2, and summarize the current literature on CLE occurring after COVID‐19 vaccination.

Keywords: adenoviral vector; lupus erythematosus; subacute cutaneous; sars cov; cutaneous lupus; vaccination

Journal Title: Clinical and Experimental Dermatology
Year Published: 2021

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