LAUSR

BACKGROUND Cutaneous lupus erythematosus (CLE) is a chronic, autoimmune skin disease with a wide spectrum of clinical presentations in different populations. OBJECTIVE To study the clinico-histological and immunological features of CLE in a multi-ethnic population and to identify the predictive factors of disease severity based on CLE disease area and severity index (CLASI) scores. METHODS This is a cross-sectional study of CLE conducted from March 2019 till February 2020. RESULTS A total of 111 patients were recruited with female to male ratio of 4.9:1. Acute CLE contributed 47.7%, followed by chronic CLE, 46.9% and subacute CLE, 5.4%. Eighty-four percent of patients had systemic lupus erythematosus. About 67.3% with chronic CLE developed systemic involvement. Anti-nuclear antibody (ANA) was detected in 90.0%. Skin biopsy(n=42) showed perivascular lymphocytic infiltration (95.2%), epidermal atrophy (47.6%) and hydropic degeneration of basal layer (47.6%). More than 40% had immunoglobulin deposition at dermo-epidermal junction, predominantly granular pattern. Mean CLASI-total was 6.44±7.70, CLASI-activity 2.75±4.10 and CLASI-damage 3.71±4.76. Body surface area (BSA) involved was found to be an independent predictive factor for CLASI-activity (OR:1.34, p=0.018). For CLASI-damage, BSA (OR:4.14, p<0.0001), discoid lupus erythematosus (DLE) subtype (OR:13.10, p=0.001), cutaneous vascular disease (OR:26.59, p=0.014), scalp involvement (OR:8.7, p=0.008) and hypocomplementemia (OR:5.71, p=0.046) were the positive predictive factors. Mean DLQI was 5.91 ± 5.34 and it correlated significantly with disease severity. CONCLUSIONS We observed a high percentage of patients with CLE with systemic manifestations and positive ANA. More aggressive treatment of those with positive predictive factors for severe disease combined with significant clinical activity may be warranted.