LAUSR

BACKGROUND Psoriasis is a chronic inflammatory skin disorder characterized by inflammation, hyperproliferation, andneoangiogenesis. The disease pathogenesis has not been fully elucidated. ADAM17 and ADAM10 are important proteases serving as regulators of inflammation. OBJECTIVES This study aimed to determine the role of ADAM17 and ADAM10 in the pathogenesis of Psoriasis through the comparison of serum ADAM17 and ADAM10 levels between Psoriasis patients and healthy controls. METHODS A total of 179 subjects, including 90 psoriasis patients and 89 healthy controls, were included in the study. Serum ADAM17 and serum ADAM10 levels were measured by the ELISA method for each participant from the patient and control groups. The statistical data analysis was performed using the SPSS 19.0 program. P-value < 0.05 was considered statistically significant. RESULTS The mean values for serum ADAM10 and ADAM17 were respectively 3.1±2.2 and 76.5±31.1 in the patient group, whereas 8.6±3.7 and 29.5±22.4 in the control group. A statistically significant difference was detected between the patient and control groups regarding ADAM10 and ADAM17 levels (p=0.0001). CONCLUSIONS Considering the high levels of ADAM17 in Psoriasis patient group, ADAM17 protease might have a crucial role in the pathogenesis of psoriasis, while the low levels of ADAM10 might be attributed to its regulatory effect on keratinocyte differentiation and proliferation.