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Altered spontaneous brain activity in Cushing's disease: a resting‐state functional MRI study

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Cushing's disease (CD) provides a unique and naturalist model for studying the influence of hypercortisolism on the human brain and the reversibility of these effects after resolution of the condition.… Click to show full abstract

Cushing's disease (CD) provides a unique and naturalist model for studying the influence of hypercortisolism on the human brain and the reversibility of these effects after resolution of the condition. This cross‐sectional study used resting‐state fMRI (rs‐fMRI) to investigate the altered spontaneous brain activity in CD patients and the trends for potential reversibility after the resolution of the hypercortisolism. We also aim to determine the relationship of these changes with clinical characteristics and cortisol levels.

Keywords: cushing disease; spontaneous brain; brain activity; resting state; brain; altered spontaneous

Journal Title: Clinical Endocrinology
Year Published: 2017

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