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Higher IGFBP3 is associated with increased incidence of colorectal cancer in older men independently of IGF1

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Insulin‐like growth factor 1 (IGF1) has anabolic and growth‐promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating IGF1 is bound to binding proteins, which modulate bioavailability of… Click to show full abstract

Insulin‐like growth factor 1 (IGF1) has anabolic and growth‐promoting effects, raising concerns regarding its potential to promote tumour growth. Circulating IGF1 is bound to binding proteins, which modulate bioavailability of IGF1. This study assessed the associations of IGF1 and its binding proteins 1 (IGFBP1) and 3 (IGFBP3) with cancer risk.

Keywords: igfbp3 associated; associated increased; incidence colorectal; cancer; increased incidence; higher igfbp3

Journal Title: Clinical Endocrinology
Year Published: 2018

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