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Pulsatility of glucocorticoid hormones in pregnancy: Changes with gestation and obesity

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Hypothalamic‐pituitary‐adrenal axis (HPA) activity is decreased in obese pregnancy and associates with increased foetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for… Click to show full abstract

Hypothalamic‐pituitary‐adrenal axis (HPA) activity is decreased in obese pregnancy and associates with increased foetal size. Pulsatile release of glucocorticoid hormones regulates their action in target tissues. Glucocorticoids are essential for normal foetal growth, but little is known about glucocorticoid pulsatility in pregnancy. We aimed to investigate the ultradian rhythm of glucocorticoid secretion during obese and lean pregnancy and nonpregnancy.

Keywords: pregnancy changes; pregnancy; glucocorticoid hormones; pulsatility glucocorticoid; hormones pregnancy

Journal Title: Clinical Endocrinology
Year Published: 2018

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