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Phenotypic diversity and glucocorticoid sensitivity in patients with familial partial lipodystrophy type 2

Familial partial lipodystrophy type 2 (FPLD2) is characterized by insulin resistance, adipose atrophy of the extremities and central obesity. Due to the resemblance with Cushing's syndrome, we hypothesized a putative… Click to show full abstract

Familial partial lipodystrophy type 2 (FPLD2) is characterized by insulin resistance, adipose atrophy of the extremities and central obesity. Due to the resemblance with Cushing's syndrome, we hypothesized a putative role of glucocorticoid in the pathogenesis of metabolic abnormalities in FPLD2.

Keywords: partial lipodystrophy; familial partial; lipodystrophy type; phenotypic diversity

Journal Title: Clinical Endocrinology
Year Published: 2019

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