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Comparative analysis of human leucocyte antigen between idiopathic and anti‐PD‐1 antibody induced isolated adrenocorticotropic hormone deficiency: A pilot study

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Adult‐onset idiopathic isolated adrenocorticotropic hormone deficiency (id‐IAD) is a rare disease with unknown aetiology. Recently, numerous cases of anti‐PD‐1 antibody‐induced IAD (PD1‐IAD) have been reported, but the clinical course, predictive… Click to show full abstract

Adult‐onset idiopathic isolated adrenocorticotropic hormone deficiency (id‐IAD) is a rare disease with unknown aetiology. Recently, numerous cases of anti‐PD‐1 antibody‐induced IAD (PD1‐IAD) have been reported, but the clinical course, predictive factors and relationship to id‐IAD have not been clarified. Moreover, associations of id‐IAD and PD1‐IAD with human leucocyte antigen (HLA) require elucidation.

Keywords: anti antibody; human leucocyte; antibody induced; adrenocorticotropic hormone; isolated adrenocorticotropic; hormone deficiency

Journal Title: Clinical Endocrinology
Year Published: 2019

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