we read the paper by Li and colleagues1 , aiming to explore the clinical significance of the BRAF p.V600E mutation in a preoperative setting, as an aid to decision-making. In… Click to show full abstract
we read the paper by Li and colleagues1 , aiming to explore the clinical significance of the BRAF p.V600E mutation in a preoperative setting, as an aid to decision-making. In order to improve the pre-operative diagnostic classification of the nodules, it has been performed BRAF p. V600E mutational analysis using amplification refractory mutation system-quantitative real-time polymerase chain reaction (ARMS-PCR) technology on samples obtained from fine-needle aspiration biopsies. Their results are somewhat unexpected and thought-provoking, but some critical issues should be highlighted before applying their results to clinical practice.
               
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