Photo from wikipedia
Human physiology and epidemiology studies have demonstrated complex interactions between the renin–angiotensin–aldosterone system, parathyroid hormone and calcium homeostasis. Several of these studies have suggested that aldosterone inhibition may lower parathyroid… Click to show full abstract
Human physiology and epidemiology studies have demonstrated complex interactions between the renin–angiotensin–aldosterone system, parathyroid hormone and calcium homeostasis. Several of these studies have suggested that aldosterone inhibition may lower parathyroid hormone (PTH) levels. The objective of this study was to assess the effect of 4 weeks of maximally tolerated mineralocorticoid receptor antagonist therapy with eplerenone on PTH levels in patients with primary hyperparathyroidism (P‐HPT) when compared to amiloride and placebo. We also investigated the synergistic effect of these interventions when combined with cinacalcet for an additional 2 weeks.
Journal Title: Clinical Endocrinology
Year Published: 2022
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!