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Association of B7H3 and B7H4 gene polymorphisms and protein expression with the development and prognosis of autoimmune thyroid diseases.

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The prognosis of autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's disease (HD), varies among patients. B7‐H3 and B7‐H4, members of the B7 family of proteins, regulate immune… Click to show full abstract

The prognosis of autoimmune thyroid diseases (AITDs), including Graves' disease (GD) and Hashimoto's disease (HD), varies among patients. B7‐H3 and B7‐H4, members of the B7 family of proteins, regulate immune response. To clarify the association of B7‐H3 and B7‐H4 with the pathogenesis and prognosis of AITDs, we examined the expression of the soluble and membrane form of B7‐H3 and B7‐H4 and genotyped single nucleotide polymorphisms (SNPs) in the B7H3 and B7H4 genes.

Keywords: prognosis; prognosis autoimmune; b7h3 b7h4; autoimmune thyroid; thyroid diseases

Journal Title: Clinical endocrinology
Year Published: 2023

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