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Dark side of astrocytes: Toxic, reactive astrocytes induced by activated microglia

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Astrocytes respond to injury and disease in the central nervous system, known as reactive astrogliosis. Liddelow et al. reported the three cytokines released by microglia are crucial to triggering the… Click to show full abstract

Astrocytes respond to injury and disease in the central nervous system, known as reactive astrogliosis. Liddelow et al. reported the three cytokines released by microglia are crucial to triggering the toxic astrocyte phenotype. These toxic astrocytes are also relevant to neurodegenerative and neuroimmune diseases.

Keywords: reactive astrocytes; toxic reactive; astrocytes induced; dark side; side astrocytes; astrocytes toxic

Journal Title: Clinical and Experimental Neuroimmunology
Year Published: 2017

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