LAUSR

OBJECTIVES This study aimed to evaluate the effect of photobiomodulation therapy (PBMT) on patient morbidity and donor site healing after free gingival graft (FGG) harvesting. METHODS Forty-four patients requiring FGG were selected for this trial. Individuals were randomly assigned to test group (PBMT, n=22) or control group (placebo, n=22) applied immediately after surgery, 24 and 48 hours after. Demographic, surgical-related and psychosocial variables possibly associated with treatment response were collected. The primary outcome was postoperative pain at the donor site evaluated using Visual Analogue Scale (VAS) immediately after surgery and 6, 24, 48 and 72 hours after. Secondary outcomes include medication consumption, patient-reported outcome measures (PROMs) and percentage of wound closure. RESULTS Intragroup analysis showed no differences in VASLog means for placebo group throughout the study (p>0.05), whereas a significant difference in PBMT group at 6h, 24h, 48h and 72h (p<0.05) were observed. Postoperative rescue analgesic requirement was significantly higher in the placebo group (p=0.004). The number needed to treat(NNT) was 2.43. PBMT group reported significant better function related to sleeping, going to work/school and daily routine activities, less restriction to mouth opening, chewing and food consumption, less swelling and bleeding (p<0.05), mainly in the first 48hs. PBMT group presented a significantly higher palatal wound closure at 7 days compared to placebo group (33.41 vs 21.20 respectively, p=0.024) after adjustment for confounding. No adverse effects were reported. CONCLUSIONS PBMT accelerated the pain resolution time and palatal closure, decreased rescue medication consumption and significantly improved patient satisfaction in the postoperative period.