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Nadroparin carries a potentially high risk of inducing cutaneous delayed‐type hypersensitivity responses

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Heparins are widely used for the prophylaxis/treatment of thromboembolic events. As adverse effects, heparin‐induced skin lesions occur frequently (in 7.5–39% of patients). Skin lesions may be the only clinical manifestation… Click to show full abstract

Heparins are widely used for the prophylaxis/treatment of thromboembolic events. As adverse effects, heparin‐induced skin lesions occur frequently (in 7.5–39% of patients). Skin lesions may be the only clinical manifestation of life‐threatening immune‐mediated heparin‐induced thrombocytopenia, but are commonly caused by a delayed‐type hypersensitivity response [heparin‐induced delayed‐type hypersensitivity (HIHS)]. Risk factors have not been prospectively identified.

Keywords: heparin induced; risk; type hypersensitivity; delayed type

Journal Title: Contact Dermatitis
Year Published: 2017

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