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A novel case of a brush with discomfort: allergic contact dermatitis caused by mercaptobenzothiazole in rubber components of a toothbrush

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Conflict of Interest: On behalf of all authors, the corresponding author states that there is no conflict of interest. had a history of nickel allergy, confirmed with patch testing. Her… Click to show full abstract

Conflict of Interest: On behalf of all authors, the corresponding author states that there is no conflict of interest. had a history of nickel allergy, confirmed with patch testing. Her lips improved, without resolution, with topical methylprednisolone aceponate ointment and petroleum jelly as a barrier ointment, and were further exacerbated by chilli, curry, wind and, possibly, coffee. Clinically, there was mild general dryness and slight scaling of the lips, with a focus of mild erythema in the cornices of the mouth. Irritant or allergic contact dermatitis was suspected, and patch testing was arranged. The patient was patch tested with the Australian baseline series, plus the cheilitis and toothpaste series. Epicutaneous tests were applied on the upper back, with allergens from Chemotechnique (Vellinge, Sweden) and AllergEAZE Chambers (AllergEAZE, Chatsworth, Australia), and checked at day (D) 2 and D4. Readings were performed according to the ESCD guideline (1). Reactions scored +, ++ or +++ were considered to be positive, and reactions scored ?+ were considered to be doubtful. The first patch test reading showed reactions to nickel (++), mercaptobenzothiazole (MBT) (++), mercapto mix (+), and thiomersal (?+). The second patch test reading showed reactions to nickel (+++), MBT (++), mercapto mix (+), thiomersal (+), and palladium chloride (+).

Keywords: allergic contact; novel case; contact; contact dermatitis; case brush

Journal Title: Contact Dermatitis
Year Published: 2018

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