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Intravaginal metronidazole ovule‐related allergic contact dermatitis

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A 35-year-old woman presented to our dermatology department with itchy erythema after using metronidazole intravaginal ovules. She had received the ovules from a gynaecology clinic for treatment of heavy vaginal… Click to show full abstract

A 35-year-old woman presented to our dermatology department with itchy erythema after using metronidazole intravaginal ovules. She had received the ovules from a gynaecology clinic for treatment of heavy vaginal discharge. Despite the onset of buttock-associated itchiness, she continued ovule treatment; however, itchiness expanded to the back and abdomen. The patient visited our hospital's emergency department and received 125 mg intravenous methylprednisolone; she was then referred to our dermatology department. Examination revealed mainly genital-associated erythema (Figure 1A). The thigh and lower leg exhibited welldemarcated erythema and small vesicles (Figure 1B,C). We thus prescribed 30 mg oral prednisolone for a five days, followed by dose tapering. Six weeks later, a patch test on the upper arm (where no

Keywords: ovule; dermatitis intravaginal; contact dermatitis; dermatology

Journal Title: Contact Dermatitis
Year Published: 2021

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