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CD4+ T cells inhibit the generation of CD8+ epidermal‐resident memory T cells directed against clinically relevant contact allergens

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CD8+ epidermal‐resident memory T (TRM) cells play central roles in local flare‐up responses to experimental contact allergens by inducing massive influx of neutrophils to the epidermis upon allergen challenge. Whether… Click to show full abstract

CD8+ epidermal‐resident memory T (TRM) cells play central roles in local flare‐up responses to experimental contact allergens by inducing massive influx of neutrophils to the epidermis upon allergen challenge. Whether similar immunopathogenic mechanisms are involved in the responses to clinically relevant contact allergens is unknown.

Keywords: resident memory; epidermal resident; contact; clinically relevant; contact allergens; cd8 epidermal

Journal Title: Contact Dermatitis
Year Published: 2023

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