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Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract. GISTs are generally found in stomach (60~70%), small bowel (20~30%), and rarely in colon and rectum (5%).… Click to show full abstract
Gastrointestinal stromal tumor (GIST) is the most common sarcoma of the gastrointestinal tract. GISTs are generally found in stomach (60~70%), small bowel (20~30%), and rarely in colon and rectum (5%). GISTs arise from the interstitial cells of Cajal within the submucosal and myenteric plexus. Positive staining for CD 117, remains the gold standard for diagnosis of GIST. While over 90% of GISTs stain positive for CD 117, new markers such as DOG 1 and PKCθ are being recognized as complementary markers for CD 117 negative GISTs. This article is protected by copyright. All rights reserved.
Journal Title: Colorectal Disease
Year Published: 2019
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