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A phase III randomized trial evaluating the quality of life impact of a tailored versus systematic use of defunctioning ileostomy following total mesorectal excision for rectal cancer—GRECCAR 17 trial protocol

The systematic use of a defunctioning ileostomy for 2–3 months postoperatively to protect low colorectal anastomosis ( Click to show full abstract

The systematic use of a defunctioning ileostomy for 2–3 months postoperatively to protect low colorectal anastomosis (<7 cm from the anal verge) has been the standard practice after total mesorectal excision (TME). However, stoma‐related complications can occur in 20%–60% of cases, which may lead to prolonged inpatient care, urgent reoperation and long‐term definitive stoma. A negative impact on quality of life (QoL) and increased healthcare expenses are also observed. Conversely, it has been reported that patients without a defunctioning stoma or following early stoma closure (days 8–12 after TME) have a better functional outcome than patients with systematic defunctioning stoma in situ for 2–3 months.

Keywords: use defunctioning; trial; total mesorectal; systematic use; defunctioning ileostomy; mesorectal excision

Journal Title: Colorectal Disease
Year Published: 2022

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