LAUSR

PURPOSE The cardiac output (CO) response to exercise is a useful marker to grade the prognosis and severity of Chronic Heart Failure (CHF). The recovery of the oxygen pulse (OP) is a non-invasive parameter, which is related to exercise capacity in cardiac patients. However, the relation between OP recovery and the central hemodynamic response to exercise remains to be determined. We hypothesized that an impaired OP recovery is associated with a reduced CO response to exercise in CHF patients. METHODS 61 CHF patients performed cardiopulmonary exercise test with simultaneous measurement of CO. Impaired OP recovery was defined as an overshoot during the first minute of recovery or OP at 1 min recovery as a percentage of peak OP (OPRR ) RESULTS: An OP overshoot was observed in 9% (n= 5) of patients. In these patients, peak CO and VO2 were significantly lower (peak CO 7.9±0.8 vs 11.2±4.3 L/min and peak VO2 14.1±4.7 vs 19.6±5.8 ml/min/kg). Mean relative recovery of OP was 78 ± 20%. Slow OP recovery (negative OPRR ) was seen in 13% (n=8). Peak CO and VO2 were significantly lower in the negative OPRR group (11+/-4 vs 8+/-0.7 L/min and 19.7+/- 5.9 vs 14.6 +/- 3.7ml/kg/min). There was a significant relation between OPRR and stroke volume (SV) RR (r=0.57), as well as between OPRR and a-v O2 diff RR (rs =0.4) CONCLUSION: An impaired OP recovery is associated with a reduced CO response to exercise and worse functional status. Therefore the OP recovery can be used to grade the severity of CHF.