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Myocardial perfusion reserve in patients with chronic hepatitis C before and after direct‐acting antiviral treatment—a pilot study

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Patients with chronic hepatitis C (CHC) have an increased risk of atherosclerotic cardiovascular disease which may be due to inflammation and endothelial dysfunction caused by the chronic infection. In this… Click to show full abstract

Patients with chronic hepatitis C (CHC) have an increased risk of atherosclerotic cardiovascular disease which may be due to inflammation and endothelial dysfunction caused by the chronic infection. In this prospective pilot study, we assessed, for the first time among patients with CHC the myocardial perfusion reserve (MPR) by Rubidium‐82 (82Rb) positron emission tomography (PET)/computed tomography (CT) before and after direct‐acting antiviral (DAA) treatment and compared them with biomarkers of systemic inflammation and endothelial dysfunction.

Keywords: patients chronic; chronic hepatitis; myocardial perfusion; direct acting; perfusion reserve; pilot study

Journal Title: Clinical Physiology and Functional Imaging
Year Published: 2022

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