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Reduced microRNA‐188‐3p expression contributes to apoptosis of spermatogenic cells in patients with azoospermia

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Human mutL homologl (MLH1) works coordinately in sequential steps to initiate repair of DNA mismatches, and aberrant MLH1 expression is related to spermatogenetic malfunction. In the present study, MLH1 expression… Click to show full abstract

Human mutL homologl (MLH1) works coordinately in sequential steps to initiate repair of DNA mismatches, and aberrant MLH1 expression is related to spermatogenetic malfunction. In the present study, MLH1 expression in patients with azoospermia was investigated, and moderating effects of miR‐188‐3p on MLH1 expression and spermatogenesis were identified.

Keywords: mlh1 expression; patients azoospermia; microrna 188; expression; 188 expression; reduced microrna

Journal Title: Cell Proliferation
Year Published: 2017

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