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Heat shock transcription factor 1 promotes the proliferation, migration and invasion of osteosarcoma cells

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Osteosarcoma is the most commonly diagnosed primary malignancy of bone and its overall survival rate is still very low. The molecular mechanisms underlying the progression of osteosarcoma have not been… Click to show full abstract

Osteosarcoma is the most commonly diagnosed primary malignancy of bone and its overall survival rate is still very low. The molecular mechanisms underlying the progression of osteosarcoma have not been clearly illuminated. Heat shock transcription factor 1 (HSF1) is a key regulator of the heat shock response and also plays important roles in many cancers, but its function in osteosarcoma remains unexplored.

Keywords: heat shock; shock transcription; transcription factor; osteosarcoma

Journal Title: Cell Proliferation
Year Published: 2017

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