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MLL1 promotes myogenesis by epigenetically regulating Myf5

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Mixed lineage leukaemia protein‐1 (MLL1) mediates histone 3 lysine 4 (H3K4) trimethylation (me3) and plays vital roles during early embryonic development and hematopoiesis. In our previous study, we found its… Click to show full abstract

Mixed lineage leukaemia protein‐1 (MLL1) mediates histone 3 lysine 4 (H3K4) trimethylation (me3) and plays vital roles during early embryonic development and hematopoiesis. In our previous study, we found its expression was positively correlated with embryonic myogenic ability in pigs, indicating its potential roles in mammalian muscle development. The present work aimed to explore the roles and regulation mechanisms of MLL1 in myogenesis.

Keywords: mll1 promotes; regulating myf5; mll1; promotes myogenesis; epigenetically regulating; myogenesis epigenetically

Journal Title: Cell Proliferation
Year Published: 2019

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