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Spermatogonial stem cells (SSCs), the germline stem cells (GSCs) committed to spermatogenesis in niche, can transform into pluripotent state in long‐term culture without introduction of exogenous factors, typically in p53… Click to show full abstract
Spermatogonial stem cells (SSCs), the germline stem cells (GSCs) committed to spermatogenesis in niche, can transform into pluripotent state in long‐term culture without introduction of exogenous factors, typically in p53 deficiency condition. As the guardian for genomic stability, p53 is associated with epigenetic alterations during SSCs transformation. However, the mechanism is still unknown, since complicated roles of p53 baffle our understanding of the regulating process.
Keywords:
pluripotent state;
stem cells;
spermatogonial stem;
stem
Journal Title: Cell Proliferation
Year Published: 2022
Link to full text (if available)
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Journal Title: Cell Proliferation
Year Published: 2022
Link to full text (if available)
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recommendations!