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It is unclear why adhesion‐dependent cells such as epithelium undergo anoikis without anchorage, while adhesion‐independent blood cells thrive in suspension. The adhesive machinery of these cells is similar, with the… Click to show full abstract
It is unclear why adhesion‐dependent cells such as epithelium undergo anoikis without anchorage, while adhesion‐independent blood cells thrive in suspension. The adhesive machinery of these cells is similar, with the exception of Kindlin orthologs, Kindlin 2 (K2) and Kindlin 3 (K3). Here we address how Kindlins control cell survival and proliferation in anchorage‐dependent and independent cells.
Keywords:
kindlin orthologs;
proliferation;
proliferation opposite;
survival proliferation;
opposite roles;
cell survival
Journal Title: Cell Proliferation
Year Published: 2022
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Journal Title: Cell Proliferation
Year Published: 2022
Link to full text (if available)
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recommendations!