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The effect of CCR5Δ32 on the risk of grade 3‐4 acute graft‐versus‐host disease after allogeneic hematopoietic stem cell transplantation: A systematic review and meta‐analysis

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Many studies have showed that CCR5 was involved in the pathological process of acute graft‐versus‐host disease (aGVHD). However, the relationship between CCR5Δ32, a frameshift mutation, and grade 3‐4 acute GVHD… Click to show full abstract

Many studies have showed that CCR5 was involved in the pathological process of acute graft‐versus‐host disease (aGVHD). However, the relationship between CCR5Δ32, a frameshift mutation, and grade 3‐4 acute GVHD risk has not been well established. We performed a meta‐analysis to explore the effects of CCR5 gene polymorphisms on grade 3‐4 aGVHD.

Keywords: versus host; grade acute; host disease; acute graft; graft versus; meta analysis

Journal Title: Clinical Transplantation
Year Published: 2017

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