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The stability of initial tacrolimus concentration following allogeneic hematopoietic stem cell transplantation reduces the risk of acute GVHD

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Early tacrolimus (TAC) concentrations correlate with the risk of acute graft‐versus‐host disease (aGVHD); however, whether the variability of early TAC concentrations after allo‐HSCT governs the occurrence of aGVHD remains unknown.… Click to show full abstract

Early tacrolimus (TAC) concentrations correlate with the risk of acute graft‐versus‐host disease (aGVHD); however, whether the variability of early TAC concentrations after allo‐HSCT governs the occurrence of aGVHD remains unknown. Here, we evaluate the correlation between the intrapatient variability (IPV) of initial TAC concentrations and the development of aGVHD.

Keywords: tacrolimus concentration; risk acute; initial tacrolimus; transplantation; stability initial; tac concentrations

Journal Title: Clinical Transplantation
Year Published: 2020

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