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Levels of donor‐derived cell‐free DNA and chemokines in BK polyomavirus‐associated nephropathy

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BK polyomavirus‐associated nephropathy (BKPyVAN) carries a risk of irreversible allograft injury. While detection of BK viremia and biopsy assessment are the current diagnostic gold standard, the diagnostic value of biomarkers… Click to show full abstract

BK polyomavirus‐associated nephropathy (BKPyVAN) carries a risk of irreversible allograft injury. While detection of BK viremia and biopsy assessment are the current diagnostic gold standard, the diagnostic value of biomarkers reflecting tissue injury (donor‐derived cell‐free DNA [dd‐cfDNA]) or immune activation (C‐X‐C motif chemokine ligand [CXCL]9 and CXCL10) remains poorly defined.

Keywords: polyomavirus associated; derived cell; cell free; donor derived; free dna; associated nephropathy

Journal Title: Clinical Transplantation
Year Published: 2022

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