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Exposure to tacrolimus trough levels below 6 ng/ml during the first year is associated with inferior kidney graft survival

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Accumulating data indicate that sub‐therapeutic levels of tacrolimus are associated with long‐term kidney graft loss. However, elevated doses increase the risk of infection and drug toxicity, which also threaten graft… Click to show full abstract

Accumulating data indicate that sub‐therapeutic levels of tacrolimus are associated with long‐term kidney graft loss. However, elevated doses increase the risk of infection and drug toxicity, which also threaten graft and patient longevity. We sought to determine the minimal tacrolimus level required to maintain graft survival.

Keywords: graft survival; exposure tacrolimus; kidney graft; graft; tacrolimus trough

Journal Title: Clinical Transplantation
Year Published: 2022

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