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Juvenile xanthogranuloma: A herald to the diagnosis of Erdheim‐Chester disease in an adult with acute leukemia

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A 21‐year‐old man with B‐cell acute lymphoblastic leukemia developed an eruption of multiple flesh‐colored nodules and persistent fevers. A lesional biopsy showed diffuse dermal infiltrates of histiocytes, foam cells, and… Click to show full abstract

A 21‐year‐old man with B‐cell acute lymphoblastic leukemia developed an eruption of multiple flesh‐colored nodules and persistent fevers. A lesional biopsy showed diffuse dermal infiltrates of histiocytes, foam cells, and Touton giant cells consistent with juvenile xanthogranulomatosis. Upon further investigation, the patient's constellation of findings fit criteria for Erdheim‐Chester disease.

Keywords: erdheim chester; chester disease; juvenile xanthogranuloma; xanthogranuloma herald; leukemia

Journal Title: Journal of Cutaneous Pathology
Year Published: 2018

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