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Clonal highlights: Clonal seborrheic keratoses often demonstrates p16 expression

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At times, distinguishing Bowen disease (BD) and benign seborrheic keratosis (SK) is histologically challenging, especially when SK shows clonal features (clonal seborrheic keratosis [CSK]). While p16 is often reported as… Click to show full abstract

At times, distinguishing Bowen disease (BD) and benign seborrheic keratosis (SK) is histologically challenging, especially when SK shows clonal features (clonal seborrheic keratosis [CSK]). While p16 is often reported as positive in BD and negative in SK, p16 expression in CSK is rarely studied. Here we investigate p16 immunohistochemistry in CSK, SK, and BD.

Keywords: seborrheic keratoses; p16 expression; clonal seborrheic; clonal highlights; highlights clonal

Journal Title: Journal of Cutaneous Pathology
Year Published: 2019

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