Melanoma, particularly nevoid melanoma, can masquerade as benign. Helpful differentiating features include nuclear pleomorphism, atypia, prominent nucleoli, absent maturation, and increased mitotic figures. These can be subtle and easily missed… Click to show full abstract
Melanoma, particularly nevoid melanoma, can masquerade as benign. Helpful differentiating features include nuclear pleomorphism, atypia, prominent nucleoli, absent maturation, and increased mitotic figures. These can be subtle and easily missed unless carefully sought. Thus, the “puffy shirt appearance” concept was born from a Seinfeld episode in which the namesake character unintentionally agreed to wear a pirate‐like puffy shirt. Consequently, he found himself out of place, sporting an outfit with “too much shirt in too little space”. Similarly, at low‐power, nevoid melanoma appears to have “too many cells in too little space”. This is more pronounced and easier to appreciate when there is an associated nevus, where crowded, subtly malignant melanocytes stand out from the evenly distributed, more spaced out benign melanocytes.
               
Click one of the above tabs to view related content.