with some plasma cells, later followed by adnexal atrophy, loss of periadnexal fat, and marked dermal sclerosis. Morphea profunda extends deep into subcutaneous issue and shows predominantly septal panniculitis with… Click to show full abstract
with some plasma cells, later followed by adnexal atrophy, loss of periadnexal fat, and marked dermal sclerosis. Morphea profunda extends deep into subcutaneous issue and shows predominantly septal panniculitis with septal fibrosis, fat replacement, and aggregates of lymphoplasmacytic infiltrate. Postirradiation pseudosclerodermatous panniculitis is a rare condition usually presenting as an indurated plaque with the histomorphology of lobular panniculitis with prominent septal fibrosis, adiponecrosis, lipophagic granulomata, and chronic inflammatory infiltrate of foamy histiocytes with rare lymphocytes and plasma cells. Another consideration is lupus panniculitus. Histopathologically, lupus panniculitis is a predominantly lobular lymphocytic panniculitis with hyaline fat necrosis and lymphoplasmacytic aggregates While eosinophils can be present in the inflammatory infiltrates of morphea and lupus panniculitis, the characteristic morphological features of these entities were not seen in our case. In summary, we describe a case of panniculitis with fat necrosis and numerous eosinophils, which was associated with AFG. After considering other possibilities, hypersensitivity reaction to substances released by adipocytes during fat necrosis or inflammatory cytokines may have been a culprit; however the underlying etiology of this manifestation remains uncertain. Awareness of this potential complication of AFG is important due to its clinical presentation mimicking recurrent malignancy, infection, and radiation dermatitides among others.
               
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