LAUSR

Clonal B‐cell proliferations and B‐cell lymphomas may co‐occur in the background of follicular helper T‐cell (TFH)‐derived lymphomas, most associated with EBV, which has been a well‐known fact for many years in the prototypical entity “TFH lymphoma, angioimmunoblastic‐type.” Primary cutaneous CD4+ small/medium T‐cell lymphoproliferative disorder (CD4+ PCSM‐LPD) is also a TFH‐derived clonal proliferation. We searched the archives and identified four cases of CD4+ PCSM‐LPD with accompanying clonal B‐cell proliferation (one of which showed EBER positivity), and one longstanding case of CD4+ PCSM‐LPD, in the background of which a B‐cell lymphoma had developed. These five cases broaden experience on CD4+ PCSM‐LPD with accompanying B‐cell proliferations and also support routine evaluation of these cases with EBV in situ hybridization, to better determine whether or not there is an association with EBV.