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Utility of the pattern‐based approach using BIOCHIP‐indirect immunofluorescence in the evaluation of subepidermal bullous disorders

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Subepidermal bullous disorders (SEBD) are a heterogeneous group of vesiculobullous diseases because of antibody‐mediated destruction of proteins of the dermo‐epidermal junction. Direct immunofluorescence (DIF) is the gold standard for diagnosis.… Click to show full abstract

Subepidermal bullous disorders (SEBD) are a heterogeneous group of vesiculobullous diseases because of antibody‐mediated destruction of proteins of the dermo‐epidermal junction. Direct immunofluorescence (DIF) is the gold standard for diagnosis. BIOCHIP‐indirect immunofluorescence (IIF) is a novel serological test that combines multiple target antigens in a single field. The present study aimed to evaluate the utility of the pattern‐based approach in BIOCHIP‐IIF for the diagnosis of SEBD.

Keywords: biochip indirect; indirect immunofluorescence; bullous disorders; utility pattern; subepidermal bullous; immunofluorescence

Journal Title: Journal of Cutaneous Pathology
Year Published: 2022

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