LAUSR

Mammary analogue secretory carcinoma (MASC)/secretory carcinoma is a recently described tumour with ETV6 translocation. Most published data on MASC are based on retrospective review of previously diagnosed low-grade adenocarcinomas, acinic cell carcinoma (AciCC) and low-grade mucoepidermoid carcinomas (MEC) of the salivary gland that were eventually shown to harbour ETV6 translocation. Overlapping morphological features and lack of familiarity with the tumour possibly contributes to the tumour being under recognised. In this case report, we describe ETV6-positive MASC in an 18-year-old man. In addition to vacuolated cells/histiocytoid cells and colloid-like material in the background we noticed nuclear membrane irregularities, nuclear grooving and hyalinised tissue fragments in the cell block. These additional features can serve as important diagnostic clues in making a diagnosis of MASC on cytology.