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Fine‐needle biopsy with 19G needle is effective in combination with endoscopic ultrasound‐guided tissue acquisition for genomic profiling of unresectable pancreatic cancer

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Comprehensive genomic profiling (CGP) has been approved in Japan since June 2019, enabling mutation‐specific therapy. Although tissue sampling via endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) is standard in pancreatic cancer, reports… Click to show full abstract

Comprehensive genomic profiling (CGP) has been approved in Japan since June 2019, enabling mutation‐specific therapy. Although tissue sampling via endoscopic ultrasound‐guided tissue acquisition (EUS‐TA) is standard in pancreatic cancer, reports on obtaining appropriate samples for CGP, especially for the OncoGuide NCC Oncopanel System (NOP) and FoundationOne CDx (FOne), are lacking. Therefore, we investigated the success rate and factors related to appropriate EUS‐TA sampling for CGP analysis suitability in unresectable pancreatic ductal adenocarcinoma (UR‐PDAC).

Keywords: guided tissue; genomic profiling; tissue acquisition; endoscopic ultrasound; ultrasound guided; tissue

Journal Title: Digestive Endoscopy
Year Published: 2022

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