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Hyperglycaemia‐induced human hepatocellular carcinoma (HepG2) cell proliferation through ROS‐mediated P38 activation is effectively inhibited by a xanthophyll carotenoid, lutein

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Diabetic population have a twofold to threefold increased risk of developing liver cancer, and hyperglycaemia is a prime causative factor that propends the tumour cells to undergo aggressive metabolic growth.… Click to show full abstract

Diabetic population have a twofold to threefold increased risk of developing liver cancer, and hyperglycaemia is a prime causative factor that propends the tumour cells to undergo aggressive metabolic growth. In this study, we aimed to examine the molecular mechanism by which lutein inhibits hyperglycaemia‐induced human hepatocarcinoma (HepG2) cell proliferation.

Keywords: cell proliferation; induced human; hyperglycaemia induced; hepg2 cell; hyperglycaemia

Journal Title: Diabetic Medicine
Year Published: 2021

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