Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM) and the main cause of end‐stage kidney disease (ESKD) worldwide. The pathogenesis of DN is complex,… Click to show full abstract
Diabetic nephropathy (DN) is one of the most common complications of diabetes mellitus (DM) and the main cause of end‐stage kidney disease (ESKD) worldwide. The pathogenesis of DN is complex, and cumulating evidence demonstrated that over‐activation of the complement system is involved. Complement factor B (CFB), a serine protease, drives the central amplification loop of the alternative pathway (AP) of the complement, making it a potential therapeutic target. In this study, we investigated the therapeutic potential of a piperidinyl indole derivative in db/db mice.
Journal Title: Diabetic Medicine
Year Published: 2025
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